Abstract

The most important part of preclinical imaging is the toxicity studies. The prediction of the toxicity and biodistribution of a radiopharmaceutical and determination of the dose adverse events requires these studies. Since there is production of new kind of radiopharmaceuticals constantly in nuclear medicine toxsicity studies are essential of this practice. The most important advantage of the radionuclide imaging and therapy modalities is that biodistribution and toxicity studies are relatively easy. By this specialty and computer aided analysis of the biodistribution of the radiopharmaceuticals (in organ basis calculations) there are some steps of the toxicity analysis might not be necessary contrary to other drugs. This review includes the recent studies and example analysis and literature summary about toxicity studies.