Abstract

Pediatric sarcomas are aggressive tumors seen in childhood that utilize advanced imaging methods for diagnosis, staging, and assessment of treatment response. Each subtype’s distinct clinical-histopathological features and metastatic potential present unique challenges. Nuclear medicine applications provide morphological and metabolic information for whole-body staging, restaging, visualization of viable tumor foci, guidance for biopsy when necessary, and assessment of therapeutic response. With these features, nuclear medicine imaging plays a complementary role to other imaging modalities. This review discusses the most common pediatric sarcomas, the nuclear medicine methods used, and new targets/future perspectives.